.Attribute Medicine, Published online: 18 September 2024 doi:10.1038/ s41591-024-03300-3Genomic and epidemiologic studies uncovered that an unfamiliar reassortant viral descent of the Oropouche virus, which has been flowing in the western side Amazon region of Brazil for regarding a years, is related to the latest human outbreaks in between 2022 and 2024.